The overarching mission of C2BL is to develop integrated models of structural heart diseases (SHDs) that combine high-fidelity structural imaging data, benchtop biomechanical studies, and innovative computational tools. We use these models to understated multiscale and time-course remodeling processes involved in SHDs, with the ultimate goal of building translational tools to individualize diagnosis, pharmaceutical treatments and surgical interventions.
These integrated models establish the critical link between the structural remodeling (ranging from protein to organ) and cardiovascular function, thus offering a powerful platform to optimize therapies based on the prediction of the interplay between remodeling, function, and intervention.
As part of a multidisciplinary team approach, we are working with collaborators in Texas Heart Institute at Houston, Brown University, Emory, and others. Our approach originates from critical clinical needs to create minimally-invasive and personalized therapies and aims to make a significant impact on cardiovascular public health.